Suppose you have source code eman2.tar.gz
setenv EMAN2DIR $HOME/EMAN2
setenv PATH $EMAN2DIR/bin:${PATH}
setenv LD_LIBRARY_PATH $EMAN2DIR/lib
setenv PYTHONPATH .:$HOME/EMAN2/lib
for bash in .bashrc add:
export EMAN2DIR=$HOME/EMAN2
export PATH=$PATH:$EMAN2DIR/bin
export LD_LIBRARY_PATH=$EMAN2DIR/lib
export PYTHONPATH=$PYTHONPATH:$HOME/EMAN2/lib